Pixel Power, my employer these past ten years, uses Microsoft Dynamics CRM. We don’t love it, but we need it and we really do use it. It’s taken a long time to get it worked into our corporate culture. We started with v2.0 and have since migrated to v3.0, with a further step to v4.0 coming in the next couple of months.
The move to v4.0 is really a good thing for multiple reasons. I’m told that integration with Outlook is much improved, including the ability to access CRM while offline. Also, v4 supports the Camrivox Flexor CTI plugin allowing integration with our OnSIP hosted IP-PBX.